- Salvation Army, Thomasville
- Sandwich Shop Restaurants, Thomasville
- Satellite TV Service, Thomasville
- Seafood Restaurants, Thomasville
- Secondary Schools, Thomasville
- Security Brokers & Dealers, Thomasville
- Senior Citizens Information & Services, Thomasville
- Service & Gas Station Equipment & Services, Thomasville
- Sheet Metal Contractors, Thomasville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Thomasville
- Ship & Boat Building & Repairing, Thomasville
- Shoe Stores, Thomasville - Mens, Womens & Kids Shoes
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- Shopping & Shopping Services, Thomasville
- Signs, Thomasville
- Social Services & Welfare, Thomasville
- Special Events & Party Supply Rental, Thomasville
- Specialty Stores, Thomasville
- Sporting Goods Stores, Thomasville
- State Government, Thomasville
- Steak House Restaurants, Thomasville
- Steel Manufacturers, Thomasville
- Steel Mills & Blast Furnaces, Thomasville
- Stocks & Bond Brokers, Thomasville
- Store Fronts, Thomasville - Storefront
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